4 Best Digestive Enzyme Supplements

When it comes to your health and wellness, you want to make sure you’re giving your body the very best digestive enzyme supplements. This is because they promote the breakdown of food products to encourage healthy digestion.

Supplement your diet with the best digestive health supplements to counteract feelings of discomfort and maintain digestive health. Apart from providing relief, digestive aid supplements are used to help treat irritable bowel syndrome (IBS) and reduce constipation symptoms.

Benefits of These Supplements

  • Protect against malabsorption
  • Remedies slow digestion
  • Relieves gas, bloating, cramps and diarrhea
  • Optimizes nutrient availability
  • Relieves indigestion
  • Increases energy
  • Lactase promotes healthy digestion in individuals with lactose intolerance
  • Alpha-galactosidase supplements may help reduce gas and bloating in people who cannot digest beans and sugars efficiently.
  • Pancrelipase breaks down fat and treats the symptoms of IBS. Results have shown improvement in cramping, bloating and pain.

4 Best Digestive Enzyme Supplements Reviews

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Renew Life Digest Smart Adult 50+ Care

Renew Life Digest Smart Adult 50+ Care, 45 Capsules

First of our best digestive enzyme supplements is a Renew Life capsule supplement. The supplement is a high potency formula aimed at over 50 year olds, targeting age-related enzyme deficiencies and indigestion.

The capsules are made from high quality, pure ingredients. Plant-sourced enzymes from artichoke and dandelion extract among others, ensure smooth digestion in men and women.

A fantastic blend of 25 enzymes consisting of carbohydrate, protein, fat, and fiber metabolizing enzymes, ensures your body can enjoy optimal digestion and increased nutrient availability. Although the product promotes the relief of symptoms of indigestion, it is also said to increase digestive health when taken regularly.

On the downside, as it’s a bottle of only 45 capsules this is one of the pricier supplements, especially if you’re planning on taking it every day.

Also to be noted is that this product is unsuitable for pregnant women and those with a gluten or lactose intolerance. That’s because there’s a possibility the capsules might contain trace elements of soy, milk, and wheat, as well as be positive for carcinogens (cancer-causing elements).

While Renew Life’s Digest Smart capsules for over 50’s may be 100% plant-derived and of high-potency, the product does not claim to treat the symptoms of any particular disease. Rather, it’s specifically aimed at occasional gas, bloating, and indigestion.

Therefore, this product is best suited to those experiencing occasional indigestion, or to maintain healthy digestion in over 50 year olds.


  • Aimed at over 50’s to directly treat the effects of a dwindling digestive enzyme supply
  • All enzymes are plant-derived and non-artificial, making this a completely vegetarian product
  • Enzymes present within the capsule are aimed at promoting digestion of all food groups
  • The high Enzyme Activity Values allow you to comfortably enjoy all your favorite foods
Renew Life Digest Smart Adult 50+ Care, 45 Capsules

Designs for Health Digestzymes

Designs for Health Digestzymes - Supplement with Betaine HCl + Pepsin (60 Capsules)

Designs for Health Digestzymes are a digestive health supplement taken by medical professionals. As it’s backed by 50,000 doctors, it’s one of the best digestive enzyme supplements. It was also voted #1 in the 2017 Consumer Labs survey of Health Practitioner Brands. Without a doubt, it’s Designs for Health’s top-selling enzyme supplement.

Designs for Health is a company that has been in practice since 1989. They have produced a product that is scientifically backed to act as part of a treatment plan for digestive problems.

Because it is gluten-free, dairy-free, and non-GMO, it is suitable for those wishing to treat lactose and gluten intolerance. As a lipase supplement, this product takes a holistic approach to supplementation by including enzymes that assist in all areas of digestion.

The synergistic enzyme blend in this premium supplement contains protease DPP IV, also known as dipeptidyl peptidase IV. This promotes the breakdown of casein and gluten products, while lactase ensures the breakdown of lactose.

The GastroENZ Proprietary Blend also contains lipase and ox bile, which is responsible for the breakdown of fats into fatty acids. Also, Betaine Hydrochloride (HCL) is added to this blend to ensure enough HCL is available to break down protein, carbs, and fats into natural digestion products. Along with pepsin, this assists in the effective digestion of food, as well as encourages comfortable eating at mealtimes.

All things considered, this product from Designs for Health has been voted #1 in Customer Satisfaction in 2016 – an assuring statistic to consider when comparing supplements.


  • Voted #1 in the 2017 Consumer Labs survey of Health Practitioner Brands
  • Voted #1 in Customer Satisfaction in 2016
  • Contains betaine HCL and pepsin to effectively achieve optimal digestion
  • Used by professionals
  • Contains enzymes that directly counteract lactose intolerance and gluten intolerance
  • Free of gluten and dairy
  • Non-GMO
  • Available in quantities of 60, 90, or 180 capsules
Designs for Health Digestzymes - Digestive Enzyme Supplement with Betaine HCl + Pepsin (60 Capsules)

Zenwise Health Daily Digestive Enzymes with Prebiotics and Probiotics

Zenwise Health Plus Prebiotics & Probiotics - Natural Support for Better Digestion & Lactose Absorption - for Bloating & Constipation + Gas Relief - 180 Vegetarian Capsules

Next to make it to our list of the best digestive enzyme supplements is the product by Zenwise Health. The product is conveniently available in 25, 60 and 180 capsule quantities, and is ideal for individuals who prefer an entirely natural-based product.

A host of plant-based enzymes, including prebiotics and probiotics, promote optimal digestion. They also alleviate symptoms of IBS, such as gas, bloating and stomach discomfort. Although it doesn’t claim to treat or cure any medical illnesses, the product does claim to improve digestion, energize the body, and support gut motility.

While digestive enzymes are naturally derived from the foods we eat, we don’t usually eat enough of them to sustain optimal gut function. Hence the need to add one of the best digestive enzyme supplements to your diet. The capsules contain papain, amylase, lactase, and protease, all of which aid in metabolizing food products. There are also several other natural ingredients in it to support gut health and motility.

Prebiotics and Probiotics help to maintain healthy gut flora, and its combination with digestive enzymes boosts natural metabolization and prevents intestinal distress.

Foods like green papaya, apple pectin, ginger, and turmeric are all present in specific quantities within the capsule to naturally aid digestion.

Green papaya helps digest food and break down food proteins, reduce stomach bloating and relieve discomfort. Turmeric is known to increase metabolism, as well as promote health and wellness by stimulating gut motility and soothing discomfort.

Zenwise provides a healthy, natural way to improve digestive flora using its Advanced Digestive System supplements and natural ingredients. The product is said to be ideal for active individuals following a diet or exercise program or trying to lose weight.

Furthermore, it comes with a Zenwise Health Lifetime Guarantee to ensure 100% satisfaction or your money back.


  • Available in varying quantities of 25, 60 and 180 capsules
  • Contains vital enzymes for digestion as well as natural plant-derived extracts including green papaya, apple pectin, ginger, turmeric, fennel, peppermint, and sea vegetables
  • Affordable and suitable for those seeking a daily digestive supplement
  • Guaranteed satisfaction or your money back!
Zenwise Health Digestive Enzymes Plus Prebiotics & Probiotics - Natural Support for Better Digestion & Lactose Absorption - for Bloating & Constipation + Gas Relief - 180 Vegetarian Capsules

NOW Supplements, Super Enzymes

NOW Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain, Super Enzymes,180 Capsules

Super Enzymes from NOW Supplements are also aimed at healthy digestion, which is why they are one of our best digestive enzyme supplements. They contain a host of digestive enzymes, along with bromelain and Ox Bile, to optimize digestion and nutrient availability.

Established in 1968, NOW supplements have remained a quality-conscious, pro-sustainability company. Their supplement is free of artificial ingredients and contains no wheat, gluten, soy or milk. Therefore, it’s suitable for individuals with gluten or lactose intolerance.

The product does, however, contain gelatin – a rich source of protein derived from animal collagen. As the product does not specify its origin, the possibility of it being animal-derived makes this supplement unsuitable to vegetarians.

The variety of enzymes present within the capsule make it an ideal supplement, as do its numerous accolades. Now Super Enzymes has won the following awards and titles:

  • Remedies Magazine Digestion Awards
  • Clean Eating Magazine – Clean Choice Awards
  • Better Nutrition Best of Supplements Award

Super Enzymes are formulated with bromelain, ox bile, pancreatin and papain for optimum digestion. Papaya Fruit Powder and betaine HCL are also present to support and improve the efficacy of digestion.

The comprehensive blend of all-natural products aimed at optimal digestion makes Super Enzymes a noteworthy product. However, it is worth mentioning that this product makes no mention of its ability to relieve or treat the digestive discomfort experienced by people with IBS.


  • Formulated with bromelain, ox bile, pancreatin, and papain
  • Contains natural derivatives from Papaya to promote digestive health
  • Contains betaine HCL for optimum digestion
  • Purposed to break down fat, carbs, and proteins
NOW Supplements, Super Enzymes, Formulated with Bromelain, Ox Bile, Pancreatin and Papain, Super Enzymes,180 Capsules

Final Thoughts

If you’re looking for one of the best digestive enzyme supplements, it’s imperative to invest in a product that wins on all fronts.

Designs for Health’s Digestzymes is the perfect supplement for an all-round approach to indigestion. The winning formula of key digestive enzymes and support from betaine HCL ensures it is high potency and has a positive effect on gut health.

This award-winning product is used by professionals and is free of gluten and dairy products. As a result, it is suitable for those who are gluten or lactose intolerant.